
Betulinic acid actively inhibits the enzyme elastase to prevent/correct the loss of elastic fibers responsible for skin suppleness. It stimulates collagen synthesis and inhibit inflammatory processes by protecting against protein kinases. It inhibits melanogenesis to achieve skin lightening and improve skin tone and clarity.
Cancer killer
Skin lightening
Liu, Wing-Keung; Ho, Joyce C. K.; Cheung, Florence W. K.; Liu, Bonnie P. L.; Ye, Wen-Cai; Che, Chun-Tao Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. European Journal of Pharmacology (2004), 498(1-3), 71-78.
Fulda, Simone; Jeremias, Irmela; Debatin, Klaus-Michael. Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells. Oncogene (2004), 23(46), 7611-7620.
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