$10.50 per 2 ml

In human serum, copper spontaneously binds to glycyl-histidyl-lysine (GHK), a tripeptide complex that has high affinity for the copper (II) anion. This complex has been shown in vitro and in vivo to accelerate wound healing. One study reported that the addition of GHK-copper complex to human fibroblasts induced a specific, concentration-dependent stimulation of collagen synthesis A later study demonstrated a dose-dependent stimulation of glycosaminoglycan synthesis, specifically heparan sulfate and dermatan sulfate, by adding GHK-copper complex to human skin fibroblasts.

 

We have created this 0.1% solution to be most useful in skin care products. Easy to handle but sufficiently concentrated not to liquefy a cream. We can alter the concentration of the solution upon request on wholesale orders. Pure peptide is also available to wholesale customers, contact us at jonatan@skinactives.com for information.

Add the copper peptide solution (2 mL) to 4 oz. of cream or gel.

Properties: this complex copper-peptide (GHK) will accelerate wound healing, and stimulate glycosaminoglycan and collagen synthesis.

 

Use: Add the copper peptide solution (2 mL) to 4 oz. of cream or gel.

 

Further information:  By stimulating collagen and glycosaminoglycan synthesis-characteristic features of the postinflammatory phase of wound repair-the GHK-copper complex may contribute to the formation of the extracellular matrix and promote wound healing.

 

NOTE: Amino acids are the subunits that make up a protein. Amino acids can join each other in a peptide bond through the loss of a water molecule: two amino acids joined in a peptide bond constitute a dipeptide, three a tripeptide, a five a pentapeptide, etc. A protein can be made up of just one or several polypeptides.

 

References: Rainer, M. J. A.; Rode, B. M. (1985) The complex formation of copper(II) with GHL and related peptides. Inorg. Chim. Acta:107:127-32.

 

Maquart, Francois Xavier; Pickart, Loren; Laurent, Maryvonne; Gillery, Philippe; Monboisse, Jean Claude; Borel, Jacques Paul. (1988) Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-copper(2+). FEBS Lett. 238:343-6.

 

Simeon, Alain; Wegrowski, Yanusz; Bontemps, Yannick; Maquart, Francois-Xavier. (2000) Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Journal of Investigative Dermatology:115: 962-968.

 

Wegrowski, Y.; Maquart, F. X.; Borel, J. P. (1992) Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Life Sciences:51:1049-56.

These claims have not been approved by the FDA and these products are not intended to diagnose, cure, or treat any disease.

 

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