EGF by Skin Actives, active in Revive

Epidermal Growth Factor BT

$9.50 per kit

Active ingredient in Re Vive^TM

What is a growth factor?

Growth factors, a.k.a. citokines, are naturally occuring proteins capable of stimulating cellular proliferation and cellular differentiation. Growth factors are important for the regulation a variety of cellular processes. Growth factors bind to specific receptors on the cell surfaces, only cells that have specific receptors for that particular growth factor (like a key ftiing a lock) can respond to it. Among the practical uses of EGF are its use in accelerating healing of skin and cornea. EGF was the first growth factor to be discovered and studied, but many more factors have been found since then. These growth factors differ in size, structure and, as a consequence, in the receptors and type of cell that recognize them, and the effects they have on the target cell.

Use Instructions: our Epidermal Growth Factor (EGF) is very powerful. Remember that EGF is a "signal" and not a nutrient, so you need very little for it to work! You will hardly see the EGF at the bottom of the small tube. It is kept very concentrated to preserve its activity. Store in the refrigerator until you are ready to use it.

When ready to use, add the contents of the second tube (saline solution) to the tube containing EGF and close. Mix by inverting and straightening the tube several times. The EGF is now ready for addition to 4 oz. of your cream, lotion, or serum. DO NOT BE TEMPTED to use it more concentrated than this. A growth factor is similar to a hormone: very little (it is measured in micrograms, one millionth of a gram) will go a very long way.

The CoA for our current batch of EGF can be found here: http://www.websitetoolbox.com/tool/view/mb/file?username=skinactives&id=140661

Further Information: In 1986, Stanley Cohen received the Nobel Prize (http://nobelprize.org/medicine/laureates/1986/cohen-lecture.pdf ) for his work elucidating the role of the Epidermal Growth Factor (EGF) in the regulation of cell growth and development. EGF is a growth factor that plays an important role in the regulation of cell growth, cell proliferation and differentiation. As other growth factors, it is a small protein. EGF acts by binding to specific receptors on the cell surface, starting a cascade of very organized molecular events, including increased intracellular calcium concentration, energy production and protein synthesis.

What matters to us is that application of EGF to the skin will accelerate healing and, when applied to aging skin it will increase the rate of skin renewal, which, just like endogenous EGF, decreases with age.

References:

Franklin J D; Lynch J B (1979) PLASTIC AND RECONSTRUCTIVE SURGERY Effects of topical applications of epidermal growth factor on wound healing. Experimental study on rabbit ears, 64(6), 766-70.

Mustoe, Thomas A.; Pierce, Glenn F.; Morishima, Chihiro; Deuel, Thomas F. (1991) Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. Journal of Clinical Investigation , 87(2), 694-703.

Ricotti, G.; Tappa, M. M.; Tucci, M. G.; Pugnaloni, A.; Lucarini, G.; Biagini, G.; Bertani, A.; Toschi, E.; Castaldini, C. (1993) Tissue expansion improvement: the role of epidermal growth factor. Clin. Dermatol., Journal of Materials Science: Materials in Medicine (1993), 4(4), 345-52.

Grahn, Jennifer C.; Isseroff, R. Rivkah. (2004) Human melanocytes do not express EGF receptors. Journal of Investigative Dermatology, 123(1), 244-246.

Mimura, Yoshihiro; Ihn, Hironobu; Jinnin, Masatoshi; Asano, Yoshihide; Yamane, Kenichi; Tamaki, Kunihiko (2004) Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C d signaling pathway. Journal of Investigative Dermatology, 122(6), 1390-1398.

http://en.wikipedia.org/wiki/Epidermal_growth_factor

Each Kit is enough for 4 oz of cream or lotion and can be combined with our other actives. Use in your favourite cream or purchase our Canvas base cream or Sea Kelp bioferment (sea kelp is perfect for people with oily skin).

Growth Factor

Healing

Skin Renewal

These claims have not been approved by the FDA and these products are not intended to diagnose, cure, or treat any disease.

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