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Apocynin, a.k.a. 1-(4-Hydroxy-3-methoxyphenyl)ethan-1-one, is chemically related to vanillin. It is present, at low concentrations, in vanilla extract and is also found in other plants, including Canadian hemp (Apocynum cannabinum) and Picrorhiza kurroa, a plant that grows in the Himalayas. Apocynin inhibits an enzyme, NADPH oxidase, and in so doing it decreases oxidative stress; it also has anti-inflammatory activity. It promotes the survival of stem cells and the cells derived from stem cells by promoting synthesis of collagen 17, a protein crucial to the anchoring of the new cells to the dermal/epidermal junction, preventing skin thinning and premature aging.