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Mangiferin is a xanthone, a potent antioxidant, present in mango and other plants. Mangiferin has been shown to reduce the intracellular Ca2+ concentration, an activity that may contribute to its protective effects and reduce iron neurotoxicity in cells. Also, it has been shown to be able to scavenge reactive oxygen species. Mangiferin is one of the most potent antioxidants known, and is even thought to be more potent than both vitamin C and vitamin E. The total antioxidant effect of any mango extract is due to the presence of a combination of several polyphenolic compounds and their derivatives. This active also helps eliminate the formation of dark spots and uneven skin tone.

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