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Strontium (Sr) is located below calcium in the periodic table of the elements. Sr++ is a divalent cation that may also compete with Ca++ for binding to some receptors, a capacity that may be responsible for the analgesic effect of strontium. Calcium is thought to play a role in the pain process by regulating the release of the chemicals that nerve cells use to communicate, and strontium would compete with calcium, effectively interfering with the entrance of calcium into the nerve cell.

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